• Rosette Bremmer, Bauke M de Jong, Michiel Wagemakers, Joost G Regtien, and Joukje van der Naalt.
• Department of Neurology, University and Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
• Neurocrit Care. 2010 Jun 1;12(3):362-8.

BackgroundOne of the predictive factors of outcome in traumatic brain injury is high intracranial pressure (ICP). Recently, the time course of ICP has been described but few data are available on the relation of these ICP profiles and outcome. The aim of this study is to investigate the relation of the time course of ICP with CT-findings and outcome.MethodsRetrospective analysis of prospectively collected data of 246 patients with traumatic brain injury admitted to the neurosurgical intensive care unit.ResultsEarly rise in ICP (within the first 2 days) was present in 32%, an intermediate rise (between days 3 and 5) in 34% and a late rise (after day 5) in 34% of patients. Half of the patients with a normal opening pressure (76%) developed intermediate or late ICP rise profiles. More mass lesions and sub/epidural hematomas were present in the late rise group. Patients with a late ICP rise required significant more intensive treatment (65% vs. 37 and 33%) when compared to the early and intermediate rise groups. In multiple regression analysis both ICP profiles and extracranial hematomas were related to outcome. With late ICP rise more unfavorable outcome (46 vs. 17%, P < 0.001) was seen although one in four patients showed a favorable outcome.ConclusionDuring ICP monitoring different ICP profiles are present over time. These profiles are related to CT-characteristics and outcome. The importance of early and late monitoring of ICP is underlined.

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