• Brain research · Sep 2014

    Controlled-cortical impact reduces volitional forelimb strength in rats.

    • David Pruitt, Seth Hays, Ariel Schmid, Connie Choua, Lily Kim, Jenny Trieu, Michael P Kilgard, and Robert L Rennaker.
    • The University of Texas at Dallas, School of Behavioral Brain Sciences, 800 West Campbell Road, GR41, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Texas Biomedical Device Center, 800 West Campbell Road, Richardson, TX 75080-3021, United States. Electronic address: dtp110020@utdallas.edu.
    • Brain Res. 2014 Sep 25;1582:91-8.

    AbstractTraumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitional forelimb strength and quantify forelimb weakness following traumatic brain injury. In this paper, we report the ability of the isometric pull task to measure both acute and chronic impairments in forelimb motor function following a controlled cortical impact (CCI) in rodents. Following CCI, volitional forelimb strength is reduced by 36% and remains significantly reduced after 6 weeks of post-lesion training. We also show that CCI results in impairment of multiple additional measures of forelimb function for several weeks post-injury.Copyright © 2014 Elsevier B.V. All rights reserved.

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