• Krishnamurti Matos de Araujo Sarmento Junior, Shiro Tomita, and Arthur Octavio de Avila Kós.
• Otorhinolaryngology, UFRJ.
• Braz J Otorhinolaryngol. 2009 Mar 1;75(2):280-9.

UnlabelledThe ideal adrenaline concentration remains unknown.AimCompare topical adrenaline solutions in different concentrations.Study DesignProspective, double blind, randomized trial.Patients And Methods49 patients divided in 3 groups underwent endoscopic sinus surgery, using only topical solutions of adrenaline in different concentrations (1:2,000, 1:10,000 and 1:50,000). We compared the duration of surgery, intra-operative bleeding, plasmatic levels of catecholamines, hemodynamic parameters and changes in heart rhythm.ResultsSurgery time was shorter in the group using adrenaline 1:2,000, which also showed less bleeding in all evaluations (objective and subjective - p < 0.0001). Plasmatic levels of epinephrine rose in all groups, more sharply in the 1:2,000 group. There was a trend towards elevation of blood pressure in the groups using adrenaline 1:2,000 and 1:10,000, with a greater occurrence of hypertensive peaks.DiscussionWe found a very significance bleeding difference favoring the 1:2,000. The blood pressure elevation in the 1:2,000 and 1:10,000 groups was progressive but very slow throughout the procedure, which could be associated with the anesthesia technique.ConclusionWe favor the use of topical adrenalin 1:2,000 due to a clear superiority in hemostasis. Further investigation is needed to corroborate our findings.

23 keywords...

hide…