• Ta-Jen Lee, Chi-Che Huang, Po-Hung Chang, Chee-Jen Chang, and Yi-Wei Chen.
• Department of Otolaryngology, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan.
• Otolaryngol Head Neck Surg. 2009 Feb 1;140(2):209-14.

ObjectivesTo determine the feasibility of the use of a topical vasoconstrictor for hemostasis during functional endoscopic sinus surgery.Study DesignCase-control study.Subjects And MethodsFrom May 1998 to August 2002, 226 patients (injection group) with bilateral chronic rhinosinusitis received an adrenaline injection for hemostasis during functional endoscopic sinus surgery at our tertiary referral center. After September 2002, topical adrenaline was applied for hemostasis in 226 consecutive patients (noninjection group) who underwent the same surgery. The two groups were matched by age, sex, body weight, stage of chronic rhinosinusitis, and pre-anesthesia blood pressure. The hemostatic effects in each group were analyzed.ResultsNo statistically significant differences in operation time and intraoperative blood loss were reached between the two groups of patients.ConclusionsTopical use of adrenaline achieved similar hemostatic effect compared with injection of adrenaline. Intranasal injection of a vasoconstrictor, in consideration of its adverse effects, may be avoided during surgery.

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