• Ali Movafegh, Laleh Eslamian, and Azita Dorabadi.
• Anesthesia and Analgesia Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
• Int J Gynaecol Obstet. 2011 Dec 1;115(3):224-6.

ObjectiveTo assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery.MethodsOne hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded.ResultsThe patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; P<0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39 ± 5.8 vs 43 ± 5.4 units; P=0.001).ConclusionIntravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean.Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

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