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Comparative Study
Comparison of functional fibrinogen assessment using thromboelastography with the standard von Clauss method.
- Ivo Fluger, Katerina Maderova, Martin Simek, Roman Hajek, Jana Zapletalova, and Vladimir Lonsky.
- Department of Cardiac Surgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. flugeri@fnol.cz
- Biomed Pap. 2012 Sep 1;156(3):260-1.
AimTo compare assessment of fibrinogen by thromboelastography with the standard von Clauss method.MethodsObservational prospective study.ResultsThromboelastography provides direct and complex evaluation of the entire coagulation cascade based upon changes in blood viscosity. It affects both platelets and plasma components. New application of this method measures fibrinogen contribution to coagulation as opposed to fibrinogen antigen levels measured by immunoassay. Paired samples from 117 patients before cardiopulmonary bypass were compared. A moderate correlation was found between fibrinogen and functional fibrinogen with a Spearman correlation coefficient of 0.476.ConclusionThe functional fibrinogen test is a valid point-of-care method for fibrinogen assay with a moderate correlation to the standard method.
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