• H Fritz, K Schwarzkopf, H Hoff, V Kurzweg, M Hartmann, and U Klein.
• Klinik für Anästhesiologie und Intensivtherapie des Klinikums der Friedrick-Schiller-Universität Jena.Harald.Fritz@med.uni-jena.de
• Anaesthesist. 2001 Jun 1; 50 (6): 406-10.

ObjectivePostanaesthetic shivering is common during recovery from general anaesthesia. Therefore we studied whether urapidil suppresses postanaesthetic shivering.MethodsWith written informed consent and approval of the local ethics committee, patients (ASA I-II) recovering from general anaesthesia were monitored for 1 h. Patients with continuous shivering for a period of 5 min were randomly treated either with 5 ml placebo (isotonic saline) or 25 mg urapidil in a double-blind trial. This treatment procedure was repeated if shivering did not stop. A complete suppression of shivering was appraised as a sufficient treatment.ResultsShivering occurred in 20 of the patients studied and urapidil stopped shivering in 7 out of the 10 treated patients, whereas the placebo stopped shivering in only 2 out of 10 patients (P < 0.05).ConclusionIn a placebo controlled trial, it was demonstrated that postanaesthetic shivering can be successfully treated by urapidil in 70% of the patients.

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