• Rinaldo Bellomo, Tiziana Bove, Simona Silvetti, and Roberta Meroni.
• Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy.
• J. Cardiothorac. Vasc. Anesth.. 2014 Apr 1;28(2):323-7.

ObjectiveTo investigate the ability of early urinary neutrophil gelatinase-associated lipocalin to predict postoperative complications in adult patients with ventricular dysfunction undergoing cardiac surgery.DesignProspective observational study.SettingSingle-center study, university hospital.ParticipantsFifty-six adult high-risk cardiac surgical patients with preoperative cardiac failure.InterventionsNone.Measurements And Main ResultsDemographic and clinical characteristics were obtained, and neutrophil gelatinase-associated lipocalin was measured at baseline and at several time points after surgery. Patient characteristics and neutrophil gelatinase-associated lipocalin levels were related to renal and patient outcome. On multivariate analyses, preoperative urinary neutrophil gelatinase-associated lipocalin was an independent predictor of length of intensive care stay (p = 0.004) and in-hospital stay (p = 0.04), but not of acute kidney injury or renal replacement therapy and was not associated with baseline renal function.ConclusionsIn a cohort of high-risk cardiac surgery patients, preoperative urinary neutrophil gelatinase-associated lipocalin value provided prognostic information that was independent of the onset of acute kidney injury or of preoperative renal function.Copyright © 2014 Elsevier Inc. All rights reserved.

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