• Meredith Allen, Santosh Sundararajan, Nazima Pathan, Margarita Burmester, and Duncan Macrae.
• Royal Brompton Hospital-Pediatric Intensive Care, London, United Kingdom. m.allen@rbht.nhs.uk
• Pediatr Crit Care Me. 2009 May 1;10(3):341-5.

ObjectiveTo determine the use of anti-inflammatory therapies in infants and children undergoing cardiac surgery in the United Kingdom and Ireland.DesignQuestionnaire survey.SubjectsAll centers that undertake pediatric cardiac surgery in the United Kingdom and Ireland.ResultsAll centers use at least one anti-inflammatory therapy, with 46% of centers using more than one. Both modified ultrafiltration (80%) and steroids (80%) are widely used as anti-inflammatory strategies. Among centers that use steroids, dose, preparation, and timing of steroid administered was highly variable. Heparin-bonded circuits and aprotinin are infrequently used as anti-inflammatory techniques.ConclusionAlthough anti-inflammatory interventions are believed to contribute to improved patient outcome following cardiopulmonary bypass, this survey has shown that there are still widespread variations in practice. Rather than reflecting poor clinical practice, we believe this reflects a lack of good evidence supporting clinical benefit.

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