• Rachael Mann, Alesia Sadosky, Caroline Schaefer, Rebecca Baik, Bruce Parsons, Edward Nieshoff, Brett R Stacey, Michael Tuchman, and Srinivas Nalamachu.
• Covance Market Access Services Inc, San Diego, CA, USA.
• J Int Assoc Provid AIDS Care. 2016 Mar 1; 15 (2): 114-25.

BackgroundHIV-related neuropathic pain (HIV-NeP) is common; however, the burden of HIV-NeP is not well-understood.MethodsThe cross-sectional study aimed to characterize the HIV-NeP burden. A total of 103 patients with HIV-NeP recruited during routine office visits completed a questionnaire to assess patient-reported outcomes, including pain severity, health status, sleep, mood, and lost productivity. Physicians completed a 6-month retrospective chart review.ResultsThe sample was predominantly male and not employed for pay. A majority (75.7%) of patients experienced moderate or severe pain. Pain interference, general health, physical health, and depression were worse among patients with more severe pain (all Ps < .006). Most (87.4%) patients were prescribed at least 1 medication for NeP. HIV-related neuropathic pain was associated with 36.1% work impairment. Adjusted annualized costs increased with increasing pain severity (P < .0001).ConclusionThe impact of HIV-NeP on health status, physical function, and depression increases with severity, resulting in substantial clinical and economic burden.© The Author(s) 2015.

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