-
Neuroscience letters · Mar 2015
A new rat model of neuropathic pain: complete brachial plexus avulsion.
- Le Wang, Liu Yuzhou, Zhou Yingjie, Lao Jie, and Zhao Xin.
- Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, PR China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, PR China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, PR China.
- Neurosci. Lett. 2015 Mar 4;589:52-6.
AbstractBrachial plexus avulsion (BPA) is one of the major injuries in motor vehicle accidents and may result in neuropathic pain. Accumulating evidence suggests that 30-80% of BPA developed neuropathic pain in human. In our study, complete brachial plexus avulsion (C5-T1) rats model leads to the results that 37.5% of rats had long-lasting (up to 6 months) mechanical allodynia and cold allodynia. We observed the activation of astrocyte and microglial in cervical spinal cord after BPA. Complete brachial plexus avulsion mimics human nerve root traction injury following traffic accidents. The complete BPA rat model approach human injuries and can be used for further investigations.Copyright © 2015. Published by Elsevier Ireland Ltd.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..