• Tao Yu, Zhengfei Yang, Heng Li, Youde Ding, Zitong Huang, and Yongqin Li.
• Emergency Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China ; Institute of Cardiopulmonary Cerebral Resuscitation, Sun Yat-sen University, Guangzhou 510120, China.
• Biomed Res Int. 2015 Jan 1; 2015: 279192.

ObjectiveIn this study, our aim was to investigate the effects of combined hypothermia with short duration maintenance on the resuscitation outcomes in a porcine model of ventricular fibrillation (VF).MethodsFourteen porcine models were electrically induced with VF and untreated for 11 mins. All animals were successfully resuscitated manually and then randomized into two groups: combined mild hypothermia (CH group) and normothermia group (NT group). A combined hypothermia of ice cold saline infusion and surface cooling was implemented in the animals of the CH group and maintained for 4 hours. The survival outcomes and neurological function were evaluated every 24 hours until a maximum of 96 hours. Neuron apoptosis in hippocampus was analyzed.ResultsThere were no significant differences in baseline physiologies and primary resuscitation outcomes between both groups. Obvious improvements of cardiac output were observed in the CH group at 120, 180, and 240 mins following resuscitation. The animals demonstrated better survival at 96 hours in the CH group when compared to the NT group. In comparison with the NT group, favorable neurological functions were observed in the CH group.ConclusionShort duration combined cooling initiated after resuscitation improves survival and neurological outcomes in a porcine model of prolonged VF.

19 keywords...

hide…