• Intensive care medicine · Feb 2014

    Sepsis and the innate-like response.

    • James J Douglas, TsangJennifer L YJLYDepartment of Critical Care Medicine, McMaster University, Hamilton, ON, Canada., and Keith R Walley.
    • Division of Critical Care Medicine, Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada. josh.douglas@hli.ubc.ca.
    • Intensive Care Med. 2014 Feb 1; 40 (2): 249-251.

    AbstractInnate-like lymphocytes are a recently described subset of the immune response with known antibacterial properties. This human trial in critically ill patients provides the first evidence of the drop in MAIT cells during bacterial sepsis, which compounds the already known immune defects. The persistent depletion and potential for nosocomial infections is an interesting finding and one likely to provide fertile grounds for future studies.

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