• Amedeo Merenda and Michael DeGeorgia.
• Neurological Institute, University Hospitals Case Medical Center, Cleveland, Ohio 44106-5040, USA.
• Curr. Opin. Neurol. 2010 Feb 1;23(1):53-8.

Purpose Of ReviewMalignant hemispheric infarction is associated with a high mortality rate, approximately 80%, as a result of the development of intracranial pressure gradients, brain tissue shift, and herniation. By allowing the brain to swell outwards and equalizing pressure gradients, decompressive craniectomy appears to significantly reduce the mortality to approximately 20%. This review takes a comprehensive look at the evidence highlighting the benefits and limits of decompressive craniectomy in malignant cerebral infarction.Recent FindingsThree recent European randomized trials have provided compelling evidence that decompressive hemicraniectomy for large hemispheric infarction is not only lifesaving, but also leads to improved functional outcome in patients 60 years of age or less when treated within 48 h of stroke onset.SummaryEarly decompressive hemicraniectomy (60 years old) and perhaps, when delayed beyond 48 h.

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