• Ferhat Cekmez, Fuat Emre Canpolat, Merih Cetinkaya, Seçil Aydinöz, Gokhan Aydemir, Ferhan Karademir, Osman Metin Ipcioglu, and Serdar Ümit Sarici.
• GATA Medical Faculty, Department of Neonatology, Ankara, Turkey.
• Eur. Cytokine Netw. 2011 Jun 1;22(2):113-7.

AimThe aim of this study was to evaluate the predictive value of resistin and visfatin in neonatal sepsis, and to compare these adipocytokines with C-reactive protein (CRP), procalcitonin and interleukin 6 (IL-6).Donors And MethodsA total of 62 term or near term infants with sepsis proven by positivity of blood culture, and 43 healthy infants were included in this study.ResultsThere were no statistically significant differences between the two groups as regards birthweight and gestational age. White blood cell count (p= 0.039), CRP levels (p=0.01), procalcitonin levels (p=0.01), IL-6 levels (p= 0.01), visfatin levels (p=0.01) and resistin levels (p=0.01) were significantly higher in septic infants. There was a positive correlation between visfatin, resistin and other markers (WBC, CRP, procalcitonin and IL-6). A cut-off value of 10 ng/mL for visfatin, showed 92% sensitivity and 94% specificity, and a cut-off value of 8 ng/mL for resistin showed 93% sensitivity and 95% specificity for neonatal sepsis.ConclusionIn the light of these results, visfatin and resistin can be used as a diagnostic marker similar to CRP, procalcitonin and IL-6 in neonatal sepsis. Further studies are needed to better understand the role and predictive value of these molecules in neonatal sepsis.

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