• A E Pusateri, J B Holcomb, R A Harris, M J MacPhee, N C Charles, L D Beall, and J R Hess.
• Department of Clinical Investigation, William Beaumont Army Medical Center, El Paso, TX, USA.
• Mil Med. 2001 Mar 1;166(3):217-22.

ObjectiveTo determine the effect of fibrinogen concentration of dry fibrin bandages on blood loss after grade V liver injury.MethodsTwenty-four pigs were used. Grade V liver injuries were induced and treated with dry fibrin bandages containing 0, 4, 8, or 15 mg fibrinogen/cm2. Animals were monitored for 60 minutes. Blood loss, fluid use, hematological data, and hemostasis were assessed.ResultsPost-treatment blood losses (mean and 95% confidence interval [CI]) were 1,560 mL (356-6,844), 372 mL (65-2,134), 225 mL (51-992), and 127 mL (22-732) in the 0-, 4-, 8-, and 15-mg groups, respectively. Only the 15-mg group had results significantly lower than the 0-mg group (p < 0.05). Blood loss was negatively related to fibrinogen concentration (p < 0.05).ConclusionFibrinogen concentration was inversely related to blood loss after grade V liver injury. The 15-mg formulation was the only one that significantly reduced blood loss.

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