• Crit Care · Apr 2005

    Comparative Study

    Dear vasopressin, where is your place in septic shock?

    • Martin W Duenser and Walter R Hasibeder.
    • Division of General and Surgical Intensive Care Medicine, Department of Anesthesiology and Critical Care Medicine, The Medical University of Innsbruck, Austria. csab3987@uibk.ac.at
    • Crit Care. 2005 Apr 1;9(2):134-5.

    AbstractCardiovascular failure is one of the central therapeutic problems in patients with severe infection. Although norepinephrine is a potent and, in most cases, highly effective vasopressor agent, very high dosages leading to significant side effects can be necessary to stabilize advanced shock. As a supplementary vasopressor, arginine vasopressin can reverse hemodynamic failure and significantly decrease norepinephrine dosages. Whether the promising possibility of 'bridging' advanced septic shock when the benefit/risk ratio of catecholamine therapy leaves a clinically tolerable range may improve quantitative and qualitative patient outcome can only be determined by a large, prospective, randomized study.

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