• Sophia Horster, H Joachim Stemmler, Philipp C Mandel, Alexander Mück, Johanna Tischer, Andreas Hausmann, Klaus G Parhofer, and Sandra Geiger.
• Medical Department II, Intensive Care Unit, Ludwig Maximilian University of Munich, Campus Großhadern, Munich, Germany.
• Onkologie. 2012 Jan 1;35(10):556-61.

BackgroundThe admission of patients with malignancies to an intensive care unit (ICU) still remains a matter of substantial controversy. The identification of factors that potentially influence the patient outcome can help ICU professionals make appropriate decisions.Patients And Methods90 adult patients with hematological malignancy (leukemia 47.8%, high-grade lymphoma 50%) admitted to the ICU were analyzed retrospectively in this single-center study considering numerous variables with regard to their influence on ICU and day-100 mortality.ResultsThe median simplified acute physiology score (SAPS) II at ICU admission was 55 (ICU survivors 47 vs. 60.5 for non-survivors). The overall ICU mortality rate was 45.6%. With multivariate regression analysis, patients admitted with sepsis and acute respiratory failure had a significantly increased ICU mortality (sepsis odds ratio (OR) 9.12, 95% confidence interval (CI) 1.1- 99.7, p = 0.04; respiratory failure OR 13.72, 95% CI 1.39-136.15, p = 0.025). Additional factors associated with an increased mortality were: high doses of catecholamines (ICU: OR 7.37, p = 0.005; day 100: hazard ratio (HR) 2.96, p < 0.0001), renal replacement therapy (day 100: HR 1.93, p = 0.026), and high SAPS II (ICU: HR 1.05, p = 0.038; day 100: HR 1.2, p = 0.027).ConclusionThe decision for or against ICU admission of patients with hematological diseases should become increasingly independent of the underlying malignant disease.Copyright © 2012 S. Karger AG, Basel.

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