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- Hazem F Elewa, Hend Hilali, David C Hess, Livia S Machado, and Susan C Fagan.
- Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Athens, Georgia 30912, USA.
- Pharmacotherapy. 2006 Apr 1;26(4):515-21.
AbstractMinocycline is a widely used tetracycline antibiotic. For decades, it has been used to treat various gram-positive and gram-negative infections. Minocycline was recently shown to have neuroprotective properties in animal models of acute neurologic injury. As a neuroprotective agent, the drug appears more effective than other treatment options. In addition to its high penetration of the blood-brain barrier, minocycline is a safe compound commonly used to treat chronic infections. Its several mechanisms of action in neuroprotection -- antiinflammatory and antiapoptotic effects, and protease inhibition -- make it a desirable candidate as therapy for acute neurologic injury, such as ischemic stroke. Minocycline is ready for clinical trials of acute neurologic injury.
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