• Intensive Care Med Exp · Dec 2015

    Mechanisms of long-term cognitive dysfunction of sepsis: from blood-borne leukocytes to glial cells.

    • Monique Michels, Amanda V Steckert, João Quevedo, Tatiana Barichello, and Felipe Dal-Pizzol.
    • Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, 88806-000, Brazil. moniquemichels@hotmail.com.
    • Intensive Care Med Exp. 2015 Dec 1;3(1):30.

    AbstractSeveral mechanisms are associated with brain dysfunction during sepsis; one of the most important are activation of microglia and astrocytes. Activation of glial cells induces changes in permeability of the blood-brain barrier, secretion of inflammatory cytokines, and these alterations could induce neuronal dysfunction. Furthermore, blood-borne leukocytes can also reach the brain and participate in inflammatory response. Mechanisms involved in sepsis-associated brain dysfunction were revised here, focusing in neuroinflammation and involvement of blood-borne leukocytes and glial cells in this process.

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