• J. Physiol. Pharmacol. · Dec 1997

    Review

    Physiologic, metabolic and mediator responses in posttrauma ARDS and sepsis: is oxygen debt a critical initiating factor?

    • J H Siegel.
    • Department of Anatomy, Cell Biology and Injury Sciences, New Jersey Medical School, UMDNJ, Newark, USA.
    • J. Physiol. Pharmacol. 1997 Dec 1;48(4):559-85.

    AbstractPosttrauma adult respiratory distress syndrome (ARDS) and sepsis initiate complex humoral and cellular inflammatory responses that initially effect the microvascular system, but rapidly extend to involve and modulate the solid organ metabolic response. It is discussed whether the interaction between these cellular processes and the organs which they involve appear to be initiated by the trauma induced oxygen debt.

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