• Yuji Kato, Toshiki Kobayashi, Hirotaka Ishido, Takeshi Hayashi, Daisuke Furuya, and Norio Tanahashi.
• Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University, Japan.
• Cephalalgia. 2013 Nov 1;33(15):1229-37.

ObjectiveThe purpose of our study was to evaluate the effect of atrial septal defect (ASD) closure on migraine headache attacks (MHA).MethodsA total of 247 patients who underwent percutaneous ASD closure at our facilities were sent a structured questionnaire. We diagnosed MHA according to the criteria of the International Headache Society.ResultsA total of 207 patients were included in the study. New-onset MHA occurred in 23 patients and persisted in 15 at a mean follow-up of 45 months. Of the 29 patients who had MHA prior to ASD closure, 11 reported exacerbation of MHA, 11 reported no change and seven reported improvement within three months after ASD closure. Compared with the patients who had no MHA, patients with de novo MHA were younger and patients with MHA improvement tended to be older. Switching from aspirin to ticlopidine or clopidogrel rapidly aborted frequent MHA in nine patients who had severe symptoms after ASD closure.ConclusionsThese results indicate that Amplatzer device implantation can act as a permanent trigger of MHA in not a few patients, and that age may be an important predictive factor of the influence of ASD closure on MHA.

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