• Samir Jaber, Gérald Chanques, Mustapha Sebbane, Farida Salhi, Jean-Marc Delay, Pierre-François Perrigault, and Jean-Jacques Eledjam.
• Critical Care and Anesthesiology Department, DAR B, Saint Eloi Hospital, University Hospital of Montpellier, Montpellier, France. s-jaber@chu-montpellier.fr
• Respiration. 2006 Jan 1;73(2):166-72.

BackgroundPatients with acute pancreatitis (AP) who require mechanical ventilation have high morbidity and mortality rates. Noninvasive positive pressure ventilation (NPPV) delivered through a mask has become increasingly popular for the treatment of acute respiratory failure (ARF) and may limit some mechanical ventilation complications.ObjectivesThe purpose of this retrospective, observational study was to evaluate our clinical experience with the use of NPPV in AP patients with ARF.MethodsFrom 1997 to 2003, we documented clinical data, gas exchange and outcome of the 62 AP patients admitted to our intensive care unit. Patients who benefited from NPPV (success) were compared with those who failed (intubated).ResultsTwenty-nine patients were intubated at admission and 5 did not develop ARF. Of the 28 patients treated with NPPV, 15 were not intubated (54%). Both groups had a similar PaO(2)/FiO(2) ratio (142 +/- 21 vs. 133 +/- 20; p = 0.127) and severity of illness (Ranson and Balthazar scores). Presence of atelectasis, bilateral alveolar infiltrates and abdominal distension were associated with failure of NPPV. Oxygenation improved and respiratory rate decreased significantly only in the success group. Additionally, the length of stay at the intensive care unit was significantly lower in the success group.ConclusionNPPV is feasible and safe to treat ARF in selected patients with AP who require ventilatory support.

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