• Alzheimers Dement · Feb 2015

    Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance.

    • Marina Boccardi, Martina Bocchetta, Liana G Apostolova, Josephine Barnes, George Bartzokis, Gabriele Corbetta, Charles DeCarli, Leyla deToledo-Morrell, Michael Firbank, Rossana Ganzola, Lotte Gerritsen, Wouter Henneman, Ronald J Killiany, Nikolai Malykhin, Patrizio Pasqualetti, Jens C Pruessner, Alberto Redolfi, Nicolas Robitaille, Hilkka Soininen, Daniele Tolomeo, Lei Wang, Craig Watson, Henrike Wolf, Henri Duvernoy, Simon Duchesne, Clifford R Jack, Giovanni B Frisoni, and EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation.
    • LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS - S. Giovanni di Dio - Fatebenefratelli Brescia, Italy. Electronic address: mboccardifbf@gmail.com.
    • Alzheimers Dement. 2015 Feb 1;11(2):126-38.

    BackgroundThis study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.MethodsThe panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.ResultsAgreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.DiscussionConsensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…