• Seminars in neurology · Apr 2011

    Review

    Post-cardiac arrest encephalopathy.

    • Wei Xiong, Robert E Hoesch, and Romergryko G Geocadin.
    • Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
    • Semin Neurol. 2011 Apr 1;31(2):216-25.

    AbstractBrain injury continues to be a leading cause of mortality and morbidity in patients resuscitated after cardiac arrest. During periods of hypoxia and ischemia, numerous mechanisms contribute to the initial and secondary injury of the brain. Though many drugs and therapies have been evaluated for neuroprotection, only therapeutic hypothermia has been proven to be effective. Accurate prognostication after cardiac arrest is essential, and can be achieved with careful neurologic examination and several ancillary tests utilizing neurophysiology, neuroimaging, and biochemistry. Practice guidelines are now available for prognostication and postresuscitation care, with emphasis on improving survival and quality of life. Also reviewed are a wide spectrum of postarrest neurologic complications and their targeted treatments.© Thieme Medical Publishers.

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