• Eur. J. Pharmacol. · Sep 2002

    Molsidomine attenuates N(omega)-nitro-L-argininemethylester-induced deficits in a memory task in the rat.

    • Nikolaos Pitsikas, Antonello E Rigamonti, Silvano G Cella, and Eugenio E Muller.
    • Department of Medical Pharmacology, University of Milan, via Vanvitelli 32, 20129 Milan, Italy. nikpit@yahoo.it
    • Eur. J. Pharmacol. 2002 Sep 27;452(1):83-6.

    AbstractThe present study was designed to investigate the role of nitric oxide (NO) on recognition memory in the rat. For this purpose, the effects on memory exerted by post-training administration of the NO synthase (NOS) inhibitor N(omega)-nitro-L-argininemethylester (L-NAME) and the NO donor molsidomine were assessed by using the object recognition task. In a first dose-response study, L-NAME, at 30 but not at 10 mg/kg impaired the animals' performance, whereas at 60 mg/kg, it induced side-effects. Molsidomine, 4 mg/kg, antagonized the L-NAME-induced performance deficits. These results indicate that NO is involved in post-training memory processes.Copyright 2002 Elsevier Science B.V.

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