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Critical care medicine · Apr 1987
Increased pulmonary alveolar-capillary permeability in patients at risk for adult respiratory distress syndrome.
- S D Tennenberg, M P Jacobs, J S Solomkin, N A Ehlers, and J M Hurst.
- Crit. Care Med. 1987 Apr 1;15(4):289-93.
AbstractTwo methods for predicting adult respiratory distress syndrome (ARDS) were evaluated prospectively in a group of 81 multitrauma and sepsis patients considered at clinical high risk. A popular ARDS risk-scoring method, employing discriminant analysis equations (weighted risk criteria and oxygenation characteristics), yielded a predictive accuracy of 59% and a false-negative rate of 22%. Pulmonary alveolar-capillary permeability (PACP) was determined with a radioaerosol lung-scan technique in 23 of these 81 patients, representing a statistically similar subgroup. Lung scanning achieved a predictive accuracy of 71% (after excluding patients with unilateral pulmonary contusion) and gave no false-negatives. We propose a combination of clinical risk identification and functional determination of PACP to assess a patient's risk of developing ARDS.
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