• Neal J Thomas, Nicole A Rizkalla, Nadir Yehya, Cheryl L Dominick, and Julie C Fitzgerald.
• Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
• J Crit Care. 2014 Apr 1;29(2):314.e1-7.

PurposeHigh-frequency percussive ventilation (HFPV) in pediatrics has been described predominantly in burned patients. We aimed to describe its effectiveness and safety in noninhalational pediatric acute respiratory failure (ARF).MethodsWe conducted an observational study in a tertiary care pediatric intensive care unit on 31 patients with ARF failing conventional ventilation transitioned to HFPV. Demographics, ventilator settings, oxygenation index, oxygen saturation index, oxygen saturation as measured by pulse oximetry/fraction of inspired oxygen (Fio2), and Pao2/Fio2 were recorded before and during HFPV.ResultsInitiation of HFPV was associated with improvements in oxygenation index, oxygen saturation index, Pao2/Fio2, and oxygen saturation as measured by pulse oximetry/Fio2 as early as 12 hours (P < .05), which continued through 48 hours after transition. Improved oxygenation occurred without an increase in mean airway pressures. Reductions in Paco2 occurred 6 hours after initiation of HFPV and continued through 48 hours (P < .01). Improved gas exchange was accompanied by reduced peak-inflating pressures at all time intervals after initiation of HPFV (P < .01). Vasopressor scores were similar before and after initiation of HFPV in patients requiring vasoactive support. Twenty-six (83.9%) of 31 patients survived to hospital discharge.ConclusionsIn a heterogeneous population of pediatric ARF failing conventional ventilation, HFPV efficiently improves gas exchange in a lung-protective manner.Copyright © 2014 Elsevier Inc. All rights reserved.

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