• Chest · Aug 2016

    Association between Occupational Exposures and Sarcoidosis: an Analysis from Death Certificates in the United States, 1988-1999.

    • Hongbo Liu, Divya Patel, Alison M Welch, Carla Wilson, Margaret M Mroz, Li Li, Cecile S Rose, Michael Van Dyke, Jeffrey J Swigris, Nabeel Hamzeh, and Lisa A Maier.
    • Division of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO; Department of Epidemiology and Biostatistics, China Medical University, Shenyang, China.
    • Chest. 2016 Aug 1; 150 (2): 289298289-98.

    BackgroundSarcoidosis is a disease that is associated with occupational and environmental antigens, in the setting of a susceptible host. The aim of this study was to examine the association between sarcoidosis mortality and previously reported occupational exposures based on sex and race.MethodsThe decedents enrolled in this study were derived from United States death certificates from 1988-1999. Cause of death was coded according to ICD-9 and ICD-10. The usual occupation was coded with Bureau of the Census Occupation Codes. Mortality odds ratio (MOR) were determined and multiple Poisson regression were performed to evaluate the independent exposure effects after adjustment for age, sex, race and other occupational exposures.ResultsOf the 7,118,535 decedents in our study, 3,393 were identified as sarcoidosis-related, including 1,579 identified as sarcoidosis being the underlying cause of death. The sarcoidosis-related MOR of any occupational exposure was 1.52 (95% CI, 1.35-1.71). Women with any exposure demonstrated an increased MOR compared to women without (MOR 1.65, 95% CI, 1.45-1.89). The mortality risk was significantly elevated in those with employment involving metal working, health care, teaching, sales, banking, and administration. Higher sarcoidosis-related mortality risks associated with specific exposures were noted in women vs men and blacks vs whites.ConclusionsFindings of prior occupations and risk of sarcoidosis were verified using sarcoidosis mortality rates. There were significant differences in risk for sarcoidosis mortality by occupational exposures based on sex and race.Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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