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Ned Tijdschr Geneeskd · Oct 1997
Case Reports[Acute perceptive hearing loss and metabolic acidosis as complications of the topical treatment of psoriasis with salicylic acid-containing ointment].
- S F Jongevos, E P Prens, J H Wolterbeek, and J M Habets.
- Afd. Dermatologie, Ziekenhuis Walcheren, Vlissingen.
- Ned Tijdschr Geneeskd. 1997 Oct 25;141(43):2075-9.
AbstractA 36-year-old woman, hospitalized because of an exacerbation of psoriasis, developed fever, sudden deafness and severe metabolic acidosis after treatment with a 10% salicylic acid containing ointment for four days. The use of salicylic acid on large areas of inflamed skin enhances the risk of transcutaneous resorption and intoxication. High serum concentrations (> 300 mg/l) of salicylic acid deregulate the blood glucose metabolism and cause damage to the inner ear. After timely intervention such symptoms are largely reversible.
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