• Acta Anaesthesiol Scand · Jan 1994

    Randomized Controlled Trial Comparative Study Clinical Trial

    Postoperative nausea and vomiting. A comparison between intravenous and inhalation anaesthesia in breast surgery.

    • E Oddby-Muhrbeck, J Jakobsson, L Andersson, and J Askergren.
    • Department of Anaesthesia and Intensive Care, Karolinska Institute of Danderyd's Hospital, Sweden.
    • Acta Anaesthesiol Scand. 1994 Jan 1;38(1):52-6.

    AbstractNausea and vomiting during the first 24 postoperative hours after breast surgery were studied. Ninety patients scheduled for elective breast surgery were randomly assigned to one of three anaesthetic methods: total intravenous anaesthesia with propofol, or propofol or thiopental for induction followed by isoflurane anaesthesia. All three groups received fentanyl for peroperative analgesia. A total of 46 (51%) patients experienced emetic sequelae: 19 (21%) complained about nausea and another 27 (30%) vomited once or more during the postoperative course. More than 50% of the patients with nausea and 70% with vomiting first suffered from these symptoms in the surgical wards after leaving the postoperative unit. Nausea and vomiting were seen in 18 (60%), 13 (43%) and 15 (50%) for the groups propofol-propofol, propofol-isoflurane and thiopental-isoflurane, respectively. In conclusion, every second patient experienced nausea or vomiting after breast surgery, the majority of these emetic symptoms occurring after leaving the postoperative unit. Propofol for induction or as a main anaesthetic did not make any major difference with regard to postoperative nausea or vomiting.

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