• Neurology · Aug 2005

    Clinical Trial

    MRI-guided, open trial of abciximab for ischemic stroke within a 3- to 24-hour window.

    • P D Mitsias, M Lu, B Silver, D Morris, J R Ewing, S Daley, C Lewandowski, A Katramados, N I Papamitsakis, H B Ebadian, Q Zhao, H Soltanian-Zadeh, D Hearshen, S C Patel, and M Chopp.
    • Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA. mitsias@neuro.hfh.edu
    • Neurology. 2005 Aug 23;65(4):612-5.

    AbstractThe authors assessed the effect of IV abciximab on early neurologic improvement and ischemic lesion growth in 29 patients with supratentorial stroke and NIH stroke scale score (NIHSSS) > or = 4 (11.1 +/- 5.9), treated within 3 to 24 (13.6 +/- 5.5) hours of onset. The 48 to 72-hour NIHSSS improvement was 4.4 +/- 3.2 and the 24-hour lesion growth on DWI was +23% (-50%, +103%); 7/26 (27%) patients experienced lesion size decrease. Treatment of sub-24-hour stroke with abciximab improves early post-treatment neurologic status and often attenuates ischemic lesion growth.

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