• Eliana Marisa Ganem, Norma Sueli Pinheiro Módolo, Fábio Ferrari, Francisco Carlos Obata Cordon, Edgar Shiguero Koguti, and Yara Marcondes Machado Castiglia.
• Departamento de Anestesiologia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Brazil.
• Rev Bras Anestesiol. 2003 Aug 1;53(4):431-9.

Background And ObjectivesLow spinal morphine doses are effective in relieving postoperative pain of patients submitted to Cesarean sections, with low incidence of side-effects. This study aimed at evaluating postoperative analgesia and the incidence of side-effects in patients submitted to Cesarean sections under spinal anesthesia with hyperbaric bupivacaine and 0.05 mg and 0.1 mg morphine associated to intravenous and oral ketoprofen.MethodsSixty pregnant women, physical status ASA I and II, undergoing elective Cesarean sections, were divided in two groups: group 1 patients were given 0.1 mg spinal morphine, while group 2 received 0.05 mg morphine, both associated to 15 mg hyperbaric bupivacaine. All patients received perioperative 100 mg intravenous ketoprofen and oral ketoprofen at 8-hour intervals in the first postoperative day. Patients were assessed at 6, 12 and 24 hours after surgery for pain intensity and side-effects (sedation, pruritus, nausea and vomiting). Side-effects were also evaluated in the perioperative period.ResultsBoth groups were similar in demographics and surgery and anesthesia duration. They were also homogeneous in postoperative pain intensity and presence of pruritus, sedation, nausea and vomiting.ConclusionsSpinal 0.05 mg and 0.1 mg morphine associated to intravenous and oral ketoprofen have provided the same postoperative analgesia and have determined the same incidence of side-effects.

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