• Samer Abu-Sultaneh, David A Hehir, Kathleen Murkowski, Nancy S Ghanayem, Jennifer Liedel, Raymond G Hoffmann, Yumei Cao, Michael E Mitchell, Andreas Jeromin, James S Tweddell, and George M Hoffman.
• 1Section of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine and Riley Hospital for Children at Indiana University Health, Indianapolis, IN. 2Division of Critical Care, Department of Pediatrics, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI. 3Division of Cardiology, Department of Pediatrics, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI. 4Division of Neonatology, Department of Pediatrics, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI. 5Division of Quantitative Health Sciences, Department of Pediatrics, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI. 6Division of Cardiothoracic Surgery, Department of Pediatrics, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI. 7Banyan Biomarkers Inc., Alachua, FL. 8Department of Pediatric Anesthesiology, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, WI.
• Pediatr Crit Care Me. 2014 Mar 1;15(3):219-28.

ObjectivesThe relationship of cerebral saturation measured by near-infrared spectroscopy with serum biomarker of brain injury S100B was investigated in infants undergoing cardiac surgery with cardiopulmonary bypass.DesignProspective cohort study.SettingSingle-center children's hospital.PatientsForty infants between 1 and 12 months old weighing greater than or equal to 4 kg with congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass were enrolled.InterventionsNone.Measurements And Main ResultsSerum S100B was measured at eight time points over 72 hours using enzyme-linked immunosorbent assay. Physiologic data including arterial, cerebral, and somatic regional oxygen saturations measured by near-infrared spectroscopy were synchronously recorded at 1-minute intervals from anesthesia induction through 72 postoperative hours. The arterial-cerebral oxygen saturation difference was calculated as the difference between arterial saturation and cerebral regional saturation. Thirty-eight patients, 5.4 ± 2.5 months old, were included in the analysis; two were excluded due to the use of postoperative extracorporeal membrane oxygenation. Seventeen patients (44.7%) had preoperative cyanosis. S100B increased during cardiopulmonary bypass in all patients, from a median preoperative baseline of mean ± SE: 0.055 ± 0.038 to a peak of 0.610 ± 0.038 ng/mL, p less than 0.0001. Patients without preoperative cyanosis had a higher S100B peak at the end of cardiopulmonary bypass. Although the absolute cerebral regional saturation on cardiopulmonary bypass was not associated with S100B elevation, patients who had arterial-cerebral oxygen saturation difference greater than 50 at any time during cardiopulmonary bypass had a higher S100B peak (mean ± SE: 1.053 ± 0.080 vs 0.504 ± 0.039 ng/mL; p < 0.0001).ConclusionsA wide cerebral arteriovenous difference measured by near-infrared spectroscopy during cardiopulmonary bypass is associated with increased serum S100B in the perioperative period and may be a modifiable risk factor for neurological injury.

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