• Di Yi Jun Yi Da Xue Xue Bao · Oct 2004

    [Role of pancreatic enzymes in gut injury secondary to trauma/hemorrhagic shock in rats].

    • Han-ping Shi, Ying Wen, Ce Zhang, Qi Xue, and Shang-tong Lei.
    • Department of Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. shihp38@hotmail.com
    • Di Yi Jun Yi Da Xue Xue Bao. 2004 Oct 1;24(10):1137-9.

    ObjectiveTo test the hypothesis that pancreatic digestive enzymes are involved in trauma/hemorrhagic shock (T/HS)-induced intestinal injury.MethodsMale Sprague-Dawley rats were given pancreatic enzyme inhibitor (6-amidino-2 -naphthyl p-guanidinobenzoate dimethanesulfonate, ANGD) intraluminally or intravenously after laparotomy (trauma), and then subjected to 90 min of hemorrhagic shock or sham shock. Intestinal injury was assessed 3 h after resuscitation with Ringer's lactate solution.ResultsHistological analysis demonstrated fewer injured villi in shock rats with intraluminal ANGD treatment than in those with intravenous ANGD administration and control shock rats. Furthermore, intestinal intraluminal perfusion of Ringer's lactate solution without ANGD produced a certain degree of protection against T/HS-induced intestinal injury, as compared with the rats without perfusion.ConclusionPancreatic proteolytic enzymes in ischemic gut may serve as important toxic factors contributing to gut injury following T/HS.

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