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J. Antimicrob. Chemother. · Dec 2006
Evaluation of anti-pneumococcal capsular antibodies as adjunctive therapy in experimental pneumococcal meningitis.
- Christian T Brandt, Niels Frimodt-Møller, Jens D Lundgren, Michael Pedersen, Ian C Skovsted, Ian J Rowland, and Christian Østergaard.
- National Center for Antimicrobials and Infection Control, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark. ctb@ssi.dk
- J. Antimicrob. Chemother. 2006 Dec 1;58(6):1291-4.
ObjectiveBacteraemia concomitant with meningitis has been shown to greatly affect outcome. Consequently, the efficacy of serotype-specific anti-pneumococcal antiserum (APAS) was investigated in a rat model of pneumococcal meningitis.MethodsRats were infected with Streptococcus pneumoniae serotype 3. All rats received ceftriaxone starting 26 h post-infection. APAS was administered either at the time of infection or 26 h post-infection and effects were compared with rats treated with antibiotics only.Results And ConclusionA significant clinical benefit was found when APAS was given at the time of infection whereas no effect was found when administered 26 h after infection. This work indicates that the clinical value of using APAS in pneumococcal meningitis may be limited.
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