• Clinics in chest medicine · Dec 2013

    Review

    Combination therapy in pulmonary arterial hypertension.

    • Meredith E Pugh, Anna R Hemnes, and Ivan M Robbins.
    • Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University, T1218 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232, USA.
    • Clin. Chest Med. 2013 Dec 1;34(4):841-55.

    AbstractDespite major advances in understanding the mechanisms of disease and development of specific drug therapy, pulmonary arterial hypertension (PAH) remains a progressive, fatal disease. At present there are 3 classes of drug therapy for PAH: prostaglandins, endothelin receptor antagonists, and phosphodiesterase-5 inhibitors. To maximize therapeutic benefit, and according to national and international guidelines, many patients are treated with combinations of these medications. This review presents a detailed account of the published data on the use of combination therapy in PAH. There are few randomized, placebo-controlled trial data to strongly support efficacy of most combination therapy, particularly oral combination therapy.Copyright © 2013 Elsevier Inc. All rights reserved.

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