• R Voswinckel, M M Hoeper, T Kramm, and H A Ghofrani.
• Medizinische Klinik II/V, Universitätsklinikum Gießen und Marburg GmbH, Standort Gießen, Mitglied des Deutschen Zentrums für Lungenforschung (DZL), Klinikstrasse 33, Gießen, Germany. robert.voswinckel@uglc.de
• Internist (Berl). 2012 May 1;53(5):545-56.

AbstractRight-sided heart failure is a severe and often life-threatening complication of chronic pulmonary hypertension. The detection of trigger factors that induce right heart failure in previously stable patients is important to initiate a causal therapeutic strategy. Pulmonary embolism (PE) is a frequent cause of acute right heart failure and therapeutic strategies for PE are well documented in the current guidelines. Treatment of choice for chronic thromboembolic pulmonary hypertension (CTEPH) is surgical pulmonary endarterectomy (PEA) and patients with possible CTEPH should be referred to an experienced PEA surgeon without delay. Intensive care management for overt right heart failure is complex and includes the use of pulmonary vasodilators, individual adjustment of diuretic or volume therapy, augmentation of myocardial contractility and left ventricular afterload. Therapeutic regimens aim at optimized filling of the right ventricle, improvement of myocardial perfusion by avoiding tachycardia, elevating systemic pressure and reducing right ventricular afterload. Early communication with a specialized center for pulmonary hypertension is recommended.

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