• Samuel M Keim, Brian L Erstad, John C Sakles, and Virgil Davis.
• Department of Emergency Medicine, Arizona Health Sciences Center, Tucson, USA. sam@aemrc.arizona.edu
• Pharmacotherapy. 2002 May 1;22(5):586-92.

Study ObjectiveTo review our experience with etomidate in nonintubated patients in the emergency department.DesignA 2-year retrospective chart review of consecutive patients receiving etomidate for sedation.SettingEmergency department of a university-based teaching hospital.PatientsForty-eight patients who underwent painful procedures in the emergency department.Measurements And Main ResultsDemographics, dosing information, recovery times, and adverse events were abstracted using a standardized data collection form. Forty-eight nonintubated patients were sedated with etomidate. Mean age was 34 years (range 6-80 yrs); 38 were men and 10 women; two were children. The mean initial dose of etomidate was 13 mg. Adverse events occurred in 11 (21%) patients. None sustained any substantial morbidity as indicated by need for intubation, prolonged emergency department stay, or hospital admission.ConclusionAlthough controversial, etomidate holds promise as a potent sedative agent for patients undergoing painful procedures in the emergency department. A large prospective evaluation is needed to document the performance and complications of this agent.

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