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Case Reports
Recurrent refractory arterial thromboembolism associated with the Janus kinase 2 V617F mutation.
- Faisal R Ali, Lara N Roberts, Hiren Mistry, Raj K Patel, Robert A Edmondson, and Roopen Arya.
- Department of Vascular Surgery, Kings College Hospital, London, United Kingdom. faisal.ali@kch.nhs.uk
- J. Vasc. Surg. 2009 Jan 1;49(1):211-3.
AbstractWe report two patients with peripheral vascular disease requiring multiple bilateral radiologic and surgical interventions, and whose disease was unresponsive to conventional anticoagulation and antiplatelet therapy. Although thrombocytosis was only intermittent, analysis of the Janus kinase 2 (JAK2) gene revealed a V617F mutation, thus confirming the presence of an underlying occult myeloproliferative disorder. We propose that JAK2 mutation analysis be considered in patients with recurrent, unexplained arterial events to identify those with occult myeloproliferative disorders.
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