• E J Giamarellos-Bourboulis, I Tsangaris, Th Kanni, M Mouktaroudi, I Pantelidou, G Adamis, S Atmatzidis, M Chrisofos, V Evangelopoulou, F Frantzeskaki, P Giannopoulos, G Giannikopoulos, D Gialvalis, G M Gourgoulis, K Kotzampassi, K Katsifa, G Kofinas, F Kontopidou, G Koratzanis, V Koulouras, A Koutsikou, M Koupetori, I Kritselis, L Leonidou, A Mega, V Mylona, H Nikolaou, S Orfanos, P Panagopoulos, E Paramythiotou, A Papadopoulos, X Papanikolaou, M Pavlaki, V Polychronopoulos, A Skoutelis, A Theodotou, M Vassiliaghou, E E Douzinas, C Gogos, A Armaganidis, and Hellenic Sepsis Study Group.
• 4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece. giamarel@ath.forthnet.gr
• J. Hosp. Infect. 2011 Jan 1;77(1):58-63.

AbstractThis study explores the role of procalcitonin (PCT) in predicting the outcome of sepsis. In a prospective multicentre observational investigation, blood was sampled within 24 h of onset of sepsis in 1156 hospitalised patients; 234 were in the intensive care unit (ICU) at the point of presentation of sepsis while 922 were not. PCT was estimated in serum by the ultrasensitive Kryptor assay in a double-blinded fashion. Among patients outside the ICU, mortality was 8% in those with PCT ≤0.12 ng/mL but 19.9% in those with PCT >0.12 ng/mL [P<0.0001, odds ratio (OR) for death: 2.606; 95% confidence interval (CI): 1.553-4.371]. Among patients whose sepsis presented in ICU, mortality was 25.6% in those with PCT ≤0.85 ng/mL but 45.3% in those with PCT >0.85 ng/mL (P=0.002; OR for death: 2.404; 95% CI: 1.385-4.171). It is concluded that PCT cut-off concentrations can contribute to predicting the outcome of sepsis and might be of particular value in identifying patients who would benefit from ICU admission.Copyright © 2010 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.

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