• Immunity · Apr 2007

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    A signal for the caspase-1 inflammasome free of TLR.

    • Charles A Dinarello.
    • Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue B168, Denver, CO 80262, USA. cdinare333@aol.com
    • Immunity. 2007 Apr 1;26(4):383-5.

    AbstractSecretion of the proinflammatory cytokine IL-1beta requires caspase-1 and Toll-like receptor (TLR) signaling. However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1beta precursor independently of TLRs.

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