• Oscar A Ingaramo, Thienkim Ngo, Robinder G Khemani, and Christopher J L Newth.
• 1Department of Pediatric Critical Care, Sunrise Children's Hospital, Las Vegas, NV. 2Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA.
• Pediatr Crit Care Me. 2014 Jan 1;15(1):15-20.

ObjectivesTo evaluate the impact of different levels of positive end-expiratory pressure on cardiac index in children receiving mechanical ventilation. To explore the effect of lung recruitment on the relationship between positive end-expiratory pressure and cardiac output.DesignProspective, single center, and interventional.SettingPICU in a tertiary care children's hospital.PatientsFifty mechanically ventilated, hemodynamically stable children between 1 month and 20 years old.InterventionsPositive end-expiratory pressure was altered to levels of 0, 4, 8, and 12 cm H2O in random order. Cardiac output was measured at different levels of positive end-expiratory pressure by continuous wave Doppler ultrasound (ultrasound cardiac output monitor). Baseline vital signs were recorded, as well as cardiac index and dynamic compliance of the respiratory system at each positive end-expiratory pressure level.Measurements And Main ResultsMedian cardiac index decreased marginally as positive end-expiratory pressure increased, with a median change in cardiac index of 0.4 (< 10%) between positive end-expiratory pressure of 0 and 12 cm H2O (p < 0.001). There was no difference in heart rate or blood pressure as positive end-expiratory pressure increased (p > 0.5). For a subset of 29 patients (58%) in whom the highest dynamic compliance was at a positive end-expiratory pressure of 4 or 8 cm H2O, there was no difference in cardiac index between positive end-expiratory pressure 4 below versus positive end-expiratory pressure at highest dynamic compliance, or cardiac index between positive end-expiratory pressure 4 above versus positive end-expiratory pressure at highest dynamic compliance (p > 0.2). Regardless of optimal dynamic compliance, cardiac index decreased as positive end-expiratory pressure increased (p = 0.02).ConclusionsIn hemodynamically stable mechanically ventilated children, although there is a statistically significant decrease in cardiac output as positive end-expiratory pressure is increased between 0 and 12 cm H2O, the mean change is less than 10%, and this is likely not clinically significant. In the presence of lung disease, intensive care physicians should feel less reluctant in their use of positive end-expiratory pressure for hemodynamically stable patients.

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