• Hitomi Ogata, Kumpei Tokuyama, Shoichiro Nagasaka, Takeshi Tsuchita, Ikuyo Kusaka, Shun Ishibashi, Hiroaki Suzuki, Nobuhiro Yamada, Kumiko Hamano, Ken Kiyono, Zbigniew R Struzik, and Yoshiharu Yamamoto.
• Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo, Tokyo 113-0033, Japan.
• Metab. Clin. Exp. 2012 Jul 1;61(7):1041-50.

AbstractGlucose dynamics measured in ambulatory settings are fluid in nature and exhibit substantial complexity. We recently showed that a long-range negative correlation of glucose dynamics, which is considered to reflect blood glucose controllability over a substantial period, is absent in patients with diabetes mellitus. This was demonstrated using detrended fluctuation analysis (DFA), a modified random-walk analysis method for the detection of long-range correlations. In the present study, we further assessed the relationships between the established clinical indices of glycemic or insulinogenic control of hemoglobin A(1c) (HbA(1c)), glycated albumin (GA), 1,5-anhydroglucitol, and urine C-peptide immunoreactivity and the recently proposed DFA-based indices obtained from continuous glucose monitoring in 104 Japanese diabetic patients. Significant correlations between the following parameters were observed: (1) HbA(1c) and the long-range scaling exponent α(2) (r = 0.236, P < .05), (2) GA and α(2) (r = 0.254, P < .05), (3) GA and the short-range scaling exponent α(1) (r = 0.233, P < .05), and (4) urine C-peptide immunoreactivity and the mean glucose fluctuations (r = -0.294, P < .01). Therefore, we concluded that increases in the long-range DFA scaling exponent, which are indicative of the lack of a long-range negative correlation in glucose dynamics, reflected abnormalities in average glycemic control as clinically determined using HbA(1c) and GA parameters.Copyright © 2012 Elsevier Inc. All rights reserved.

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