• Obstet. Gynecol. Clin. North Am. · Jun 2014

    Review

    Buprenorphine and methadone for opioid addiction during pregnancy.

    • Ellen L Mozurkewich and William F Rayburn.
    • Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, MSC 10 5580, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: emozurkewich@salud.unm.edu.
    • Obstet. Gynecol. Clin. North Am. 2014 Jun 1;41(2):241-53.

    AbstractBuprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use. As part of a comprehensive care plan, such therapy may result in improved access to prenatal care, reduced illicit drug use, reduced exposure to infections associated with intravenous drug use, and improved maternal nutrition and infant birth weight. This article describes differences in patient selection between the two drugs, their relative safety during pregnancy, and changes in daily doses as a guide for prescribing clinicians.Copyright © 2014 Elsevier Inc. All rights reserved.

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