• Eur J Pain · Apr 2005

    Review

    Opioids and central sensitisation: II. Induction and reversal of hyperalgesia.

    • Ruth Ruscheweyh and Jürgen Sandkühler.
    • Department of Neurophysiology, Centre for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria.
    • Eur J Pain. 2005 Apr 1;9(2):149-52.

    AbstractOpioids are powerful analgesics when used to treat acute pain and some forms of chronic pain. In addition, opioids can preempt some forms of central sensitization. Here we review evidence that opioids may also induce and perhaps reverse some forms of central sensitization.

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