• Pierre Kalfon, Bruno Giraudeau, Carole Ichai, Alexandre Guerrini, Nicolas Brechot, Raphaël Cinotti, DequinPierre-FrançoisPFService de Réanimation médicale, Hôpital Bretonneau, CHRU de Tours, Tours, France., Béatrice Riu-Poulenc, Philippe Montravers, Djilalli Annane, Hervé Dupont, Michel Sorine, Bruno Riou, and CGAO–REA Study Group.
• Service de Réanimation polyvalente, Hôpital Louis Pasteur, Hôpitaux de Chartres, Chartres Cedex, 28018, Le Coudray, France. pkalfon@ch-chartres.fr.
• Intensive Care Med. 2014 Feb 1; 40 (2): 171-181.

PurposeThe blood glucose target range and optimal method to reach this range remain a matter of debate in the intensive care unit (ICU). A computer decision support system (CDSS) might improve the outcome of ICU patients through facilitation of a tighter blood glucose control.MethodsWe conducted a multi-center randomized trial in 34 French ICU. Adult patients expected to require treatment in the ICU for at least 3 days were randomly assigned without blinding to undergo tight computerized glucose control with the CDSS (TGC) or conventional glucose control (CGC), with blood glucose targets of 4.4-6.1 and <10.0 mmol/L, respectively. The primary outcome was all-cause death within 90 days after ICU admission.ResultsOf the 2,684 patients who underwent randomization to the TGC and CGC treatment groups, primary outcome was available for 1,335 and 1,311 patients, respectively. The baseline characteristics of these treatment groups were similar in terms of age (61 ± 16 years), SAPS II (51 ± 19), percentage of surgical admissions (40.0%) and proportion of diabetic patients (20.3%). A total of 431 (32.3%) patients in the TGC group and 447 (34.1%) in the CGC group had died by day 90 (odds ratio for death in the TGC 0.92; 95% confidence interval 0.78-1.78; p = 0.32). Severe hypoglycemia (<2.2 mmol/L) occurred in 174 of 1,317 patients (13.2%) in the TGC group and 79 of 1,284 patients (6.2%) in the CGC group (p < 0.001).ConclusionsTight computerized glucose control with the CDSS did not significantly change 90-day mortality and was associated with more frequent severe hypoglycemia episodes in comparison with conventional glucose control.

15 keywords...

hide…