• Valerie E Whiteman, Luminita Crisan, Cheri McIntosh, A P Alio, Jingyi Duan, Phillip J Marty, and Hamisu M Salihu.
• Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of South Florida, 2A Tampa General Circle, Tampa, FL 33606, USA. vwhitema@health.usf.edu
• Gynecol. Obstet. Invest. 2011 Jan 1;72(3):192-5.

Background/AimsTo examine the association between interpregnancy body mass index (BMI) change and stillbirth.MethodsRetrospective study using Missouri maternally linked cohort files (1978-2005). A total of 218,389 women were used in the analysis. BMI was classified as: underweight (<18.5), normal (18.5-24.9), overweight (25-29.9), or obese (≥30.0). Weight change was defined based on BMI category (i.e. normal-normal, normal-obese, etc.). Cox proportional hazard regression models were used to generate adjusted hazard ratios (HR) and 95% CI for the risk of stillbirth in the second pregnancy.ResultsSignificant findings were associated with interpregnancy BMI changes involving overweight mothers becoming obese (HR = 1.4, 95% CI 1.1-1.7), normal-weight mothers becoming overweight (HR = 1.2, 95% CI 1.0-1.4) or obese (HR = 1.5, 95% CI 1.1-2.1), or obese mothers maintaining their obesity status across the two pregnancies (HR = 1.4, 95% CI 1.2-1.7). Other weight change categories did not show significant risk elevation for stillbirth.ConclusionsBMI change appears to play an important role in subsequent stillbirth risk.Copyright © 2011 S. Karger AG, Basel.

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