• M Dworschak, A Lassnigg, G Tenze, D Zimpfer, M Czerny, M Grimm, R Schmid, and G Grubhofer.
• Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, General Hospital Vienna, Austria. martin.dworshak@univie.ac.at
• Thorac Cardiovasc Surg. 2004 Feb 1;52(1):29-33.

BackgroundThe potentially harmful effects of normothermia on neurological outcome during cardiopulmonary bypass (CPB) are controversial.MethodsIn this study, we compared the early and late release patterns of S-100beta, a marker of cerebral injury, after normothermic and moderately hypothermic CPB. Forty-eight patients undergoing coronary artery bypass grafting were randomly assigned to either the normothermia (37 degrees C) or the hypothermia (32 degrees C) group. Serum S-100beta levels were measured until 24 h after CPB. Neurological examination was performed before and after surgery.ResultsWith the exception of intraoperative blood glucose levels, there were no differences between groups. This also applied to peak S-100beta values (Gr-N: 3.5 +/- 1.9 microg/l; Gr-H: 3.5 +/- 3.4 microg/l) and values after 24 h (Gr-N: 0.32 +/- 0.16 microg/l; Gr-H: 0.35 +/- 0.28 microg/l).ConclusionsThe similar pattern of S-100beta release without evident neurological complications in the normothermia group does not suggest an increase in cerebral injury during normothermic CPB.

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