• J Pediatr Urol · Dec 2010

    Longer than expected-duration of caudal analgesia with two different doses of levobupivacaine in children undergoing hypospadias repair.

    • Karl-Christian Thies, Jacques Driessen, Hing Gwan Kho, Karen Kwak, Jacqueline Knoll, Robert de Gier, and Wouter Feitz.
    • Radboud University Nijmegen Medical Centre, Dept. of Anaesthesia, The Netherlands. KCThies@hotmail.com
    • J Pediatr Urol. 2010 Dec 1;6(6):585-8.

    ObjectiveTo assess our study design and to obtain preliminary data for a dose-effect study on levobupivacaine for caudal analgesia in patients undergoing hypospadias repair.Study Designnon randomised, non-blinded pilot study.MethodFor this non-randomized, non-blinded pilot study, 20 patients (median age 17 months, median weight 10.5 kg) were allocated to two groups receiving either 0.5 mL kg(-1) levobupivacaine 0.125% (Group 0) or 0.5 mL kg(-1) levobupivacaine 0.375% (Group 1) caudally after induction of anaesthesia for pain control. No further analgesia was given before, during or after the procedure. Pain scores (Children's and Infants' Postoperative Pain Scale) were recorded throughout the observation period, which lasted from the start of the procedure until hospital discharge on the following day.ResultsGroup 0: six out of 10 patients remained pain free throughout the observation period. Group 1: six out of seven patients remained pain free throughout the observation period.ConclusionBoth concentrations of levobupivacaine provided excellent analgesia throughout surgery. The postoperative analgesia with both doses of levobupivacaine was found to be significantly longer lasting than previously reported. The study design, with a tight and extensive observation scheme, proved to be feasible, but given the surprisingly long-lasting analgesia, the observation period needs to be extended in future studies.Copyright © 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

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